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Jan 10, 2022
7:29 PM
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A process known as coagulation (also known as clotting) occurs when we cut ourselves in order to stop the bleeding. It is performed after a cut to determine how quickly the blood vessels re-close after being cut. When it comes to diagnosing the general state of the blood coagulation system as well as the severity of pathologies, they are particularly well suited. They are also particularly well suited for recording all associated influences on the blood coagulation system at the same time. At the outset of the process, global methods are critical for diagnostic purposes because they provide an integrated picture of the alterations occurring within the coagulation system and allow for predictions regarding the likelihood of a general tendency to hyper- or hypocoagulation at the time of diagnosis. It is necessary to perform a local test in order to characterize and describe the work done by the various components of the blood clotting system cascade, as well as the various Coagulation Analyzer factors present in the patient's body, in order to diagnose and treat the patient. It is possible to pinpoint the location of the pathology within the accuracy range of the coagulation machine factor in the presence of these proteins, allowing for a more accurate diagnosis.
ECL 105 - Single Channel Coagulation Analyzer
It is common for doctors to utilize physical exams and medical histories to identify coagulation system problems in patients who have already been diagnosed with the condition. An accurate diagnosis is reached after considering the patient's symptoms as well as the results of a blood test. A number of further diagnostic procedures may be performed depending on the patient's condition.
Only a blood test can determine whether or not there is an issue with the coagulation system. In addition to forming blood clots, which are an important part of the body's healing process, this system is also responsible for the development of blood vessels. If the circulatory system is not functioning properly, clogged blood arteries may prevent vital organs from receiving the blood flow they need.
An embolism is caused by the transition of blood from a liquid to a gel, which is referred to as "coagulation." Hemostasis is a technique that may be utilized to stop blood loss and enable the blood vessel to mend itself in the case of a ruptured blood vessel. In order for the coagulation process to proceed, platelets must bind to one another, aggregate, and create fibrin chains.
Immediately after an injury to the endothelium of a blood artery occurs, coagulation takes place. When blood is exposed to the subendothelial space (SEF), SEF is exposed to plasma factor VII, which results in the formation of cross-linked fibrin in the bloodstream. Following activation, platelets create a plug at the site of injury, preventing further bleeding from occurring. Thrombin (also known as factor VII) is one of numerous coagulation (clotting) factors that triggers a chain reaction that strengthens the platelet plug and stops bleeding. It is discussed in further detail below. Fibrin is generated in both the main and secondary hemostasis coagulation pathways, indicating that they are both active. Both pathways lead to the same fundamental events that result in the formation of fibrin. Two examples of this are the touch activation route and the tissue factor pathway (see below) (also known as the extrinsic pathway). Extrinsic (tissue factor) coagulation is thought to be the primary cause of blood coagulation in certain cases. Before, the intrinsic and extrinsic pathways were believed to be of equal significance. This has changed. When an enzyme is activated, its inactive zymogens (precursors) transform into active components, culminating in the formation of cross-linked fibrin as a final product. It is necessary to complete many stages in order to complete this procedure. When denoting coagulation factors, Roman numerals are often used, with a lowercase a being added to indicate that the factor is active.
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