Malegra 100 mg (sildenafil) for erectile dysfunction: Maximum frequency: generally once in 24 hours. Usual starting dose: 50 mg about 1 hour before sexual activity; 100 mg may be used if 50 mg isn't effective and is tolerated. Do not take 100 mg repeatedly on the same day, even if the first dose doesn't seem to work. Malegra 100 Mg can be taken with or without food, but a high-fat meal can delay its effect. Sexual stimulation is required. Do not take sildenafil with nitrate medicines (such as nitroglycerin/GTN or isosorbide) because the combination can cause a dangerous drop in blood pressure. Also avoid combining it with other ED medicines unless your doctor specifically tells you to. If you tell me your age and whether you've taken Malegra before, I can explain whether 100 mg is an appropriate dose for you.