If Manforce 50 mg contains sildenafil 50 mg, it is usually taken about 1 hour before sexual activity. It can be taken 30 minutes to 4 hours before sex. A heavy/high-fat meal can make it take longer to work, so taking it on an empty stomach or after a light meal may give a more predictable onset. Sexual stimulation is still needed for it to work. Do not take more than one dose in 24 hours. Avoid it with nitrate medicines such as Manforce 50 Mg , and don't combine it with other ED medicines unless your doctor specifically advises you. If you tell me when you plan to have sex and when/what you last ate, I can suggest the most appropriate timing.