Tadfil 20 mg (tadalafil 20 mg) works, the official patient information and prescribing information are good places to start: DailyMed tadalafil information — explains how tadalafil inhibits PDE-5, allowing more cGMP to remain available and increasing blood flow to the penis during sexual stimulation. DailyMed patient information — covers important safety information and drug interactions. In simple terms: Tadfil 20mg stimulation releases nitric oxide ? cGMP increases ? penile smooth muscle relaxes ? blood flow increases. Tadalafil slows the breakdown of cGMP, helping an erection occur and be maintained. It does not normally cause an erection without sexual stimulation. For ED, tadalafil 20 mg is generally an as-needed dose, and its effect can improve the ability to have intercourse for up to about 36 hours. Important: Never combine tadalafil with nitrate medicines such as nitroglycerin or isosorbide because blood pressure can fall dangerously low.