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Why does Malegra act on smooth muscles?
Why does Malegra act on smooth muscles?
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Guest
Guest
Jul 27, 2026
1:54 AM
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Malegra (sildenafil) acts on smooth muscle because its main target, phosphodiesterase type-5 (PDE-5), is found in high amounts in certain smooth muscle tissues, especially the smooth muscle of the penis (corpus cavernosum) and blood vessels. Here is the mechanism: Sexual stimulation causes release of nitric oxide (NO) in penile tissue. NO activates guanylate cyclase, which increases levels of cyclic GMP (cGMP). cGMP causes relaxation of smooth muscle in the corpus cavernosum. Relaxed Malegra muscle allows increased blood flow into the penis, producing an erection. PDE-5 normally breaks down cGMP. Sildenafil blocks PDE-5, so cGMP stays active longer and smooth muscle relaxation is enhanced. Malegra does not directly relax smooth muscle; it prevents the breakdown of the chemical signal (cGMP) that causes relaxation. PDE-5 is also present in blood vessel smooth muscle, which is why sildenafil can sometimes cause effects such as flushing, headache, and a mild drop in blood pressure.
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