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Why is Fildena Professional not combined with ?
Why is Fildena Professional not combined with ?
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kirazmattson
1211 posts
Jul 08, 2026
10:07 PM
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Fildena Professional (which contains sildenafil) should not be combined with nitrates because the combination can cause a dangerous drop in blood pressure. Here is why: Sildenafil works by blocking the enzyme PDE5, which increases a substance called cGMP. This relaxes blood vessels and improves blood flow to the penis. Nitrates (such as Nitroglycerin or Isosorbide mononitrate) also increase nitric oxide activity and raise cGMP, causing blood vessels to widen. When taken together, their effects can add up, leading to a sudden and severe fall in blood pressure. This can result in fainting, Fildena Professional attack, stroke, or a life-threatening situation. Common nitrate-containing medicines include those used for angina (chest pain), such as nitroglycerin tablets/sprays and some long-acting nitrate preparations. People using nitrates should generally avoid sildenafil unless specifically directed by a qualified clinician. If you tell me the name of any heart, chest-pain, or blood-pressure medicines you take, I can help check whether any of them are nitrates or interact with sildenafil.
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