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Paclitaxel
Paclitaxel
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Guest
Guest
May 25, 2026
11:53 PM
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Paclitaxel is a renowned diterpene alkaloid that has garnered significant attention from scientists due to its distinctive chemical structure, unique mechanism of action, potent anticancer properties, and the challenges associated with its supply.
Discovered in 1967 by Dr. Monroe Wall and Dr. Mansukh Wani at the Research Triangle Institute, paclitaxel was originally isolated from the bark of the Pacific yew tree, Taxus brevifolia. Its chemical formula is C47H51NO14, and its structure is characterized by a complex, polycyclic diterpenoid core featuring a taxane ring system. Key to its biological activity are the ester side chain at the C13 position and an oxetane ring spanning the C4-C5 positions.
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