TME promotes liver cancer cell to acquire abnormal phenotypes and recruits immune cells, such as macrophages and T cells. Tumor-associated macrophages (TAMs) are a well-known component of the TME, which take part in cancer progression and metastasis. TAM abundantly infiltrates TME and is often associated with the poor prognosis of patients with liver cancer. The important roles of TAMs include immunosuppressive function, enhancement of cancer invasion and metastasis, angiogenesis, epithelial-mesenchymal transition (EMT), and maintenance of stemness. Therefore, targeting TAMs might be critical for developing an effective therapy for liver cancer. Learn more about macrophages in Liver cancer.
