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How does Sildigra 100 Mg influence the ?
How does Sildigra 100 Mg influence the ?
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kirazmattson
121 posts
Apr 17, 2024
4:20 AM
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Sildigra 100 mg contains the active ingredient sildenafil citrate, which is a phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil citrate works by inhibiting the enzyme PDE5, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis.
To understand how Sildigra 100 mg influences the production of cGMP, it's helpful to know the normal physiological process of penile erection:
Sexual stimulation triggers the release of nitric oxide (NO) in the erectile tissue of the penis.
Nitric oxide stimulates the enzyme guanylate cyclase to produce cyclic guanosine monophosphate (cGMP) from guanosine triphosphate (GTP).
cGMP acts as a second messenger, leading to relaxation of the smooth muscle cells in the penile arteries and corpus cavernosum (erectile tissue).
Relaxation of the smooth muscle cells allows increased blood flow into the penis, resulting in an erection.
PDE5 enzymes break down cGMP, returning the smooth muscle cells to their resting state and causing the erection to subside.
By inhibiting PDE5, sildenafil citrate in Sildigra 100 prevents the degradation of cGMP. This leads to an accumulation of cGMP in the smooth muscle cells of the penis, prolonging its action and enhancing the vasodilatory effects. As a result, there is increased blood flow into the penis, which helps men achieve and maintain an erection sufficient for sexual activity.
In summary, Sildigra 100 mg influences the production of cGMP by inhibiting the enzyme PDE5, which allows cGMP levels to remain elevated, promoting penile erection and improving erectile function.
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