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What is the mechanism of action of Malegra 50 Mg ?
What is the mechanism of action of Malegra 50 Mg ?
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kirazmattson
101 posts
Apr 05, 2024
1:15 AM
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Malegra 50 mg contains sildenafil citrate, which is a medication used to treat erectile dysfunction (ED) in men. Sildenafil citrate works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is primarily found in the smooth muscle cells of the penis and pulmonary vasculature.
Here's how the mechanism of action of Malegra 50 mg works:
Erection process: During sexual arousal, the release of nitric oxide (NO) in the corpus cavernosum of the penis leads to increased levels of cyclic guanosine monophosphate (cGMP). This cGMP acts as a signaling molecule, causing relaxation of the smooth muscles in the penile arteries and corpus cavernosum. This relaxation allows blood to flow into the penis, resulting in an erection.
PDE5 inhibition: Sildenafil citrate in Malegra 50 mg inhibits the enzyme phosphodiesterase type 5 (PDE5), which is responsible for the breakdown of cGMP in the smooth muscle cells of the penis. By inhibiting PDE5, sildenafil helps to maintain higher levels of cGMP, prolonging the vasodilation and enhancing the erectile response.
Enhanced blood flow: With inhibition of PDE5, there is increased vasodilation and blood flow into the penis, leading to improved erectile function. This effect is particularly beneficial for men with erectile dysfunction, as it helps them achieve and maintain erections suitable for sexual activity.
Duration of action: The effects of sildenafil typically last for about 4 to 6 hours, during which time a man may experience improved erectile function in response to sexual stimulation.
It's important to note that Malegra 50 and other sildenafil-containing medications do not cause erections on their own; sexual arousal and stimulation are still necessary for the medication to be effective. Additionally, Malegra 50 mg should be taken as directed by a healthcare professional and should not be used without medical supervision.
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