Yes, Tazzle 20 FM, which contains Tadalafil, can interact with grapefruit juice. Grapefruit juice can inhibit the enzyme CYP3A4, which is involved in the metabolism of Tadalafil. When this enzyme is inhibited, it can lead to increased levels of Tadalafil in the bloodstream, potentially enhancing its effects and increasing the risk of side effects.

Therefore, it's generally recommended to avoid consuming grapefruit juice while taking Tazzle 20 FM or any other medication that contains Tadalafil. If you have any concerns about potential interactions between Tazzle 20 FM and grapefruit juice, it's best to consult with your healthcare provider for personalized advice. They can provide guidance on how to safely take your medication and avoid any potential interactions.