Thus the main difference between land-based slots and online slot machines is the way you interact with them. You physically take some action with a land-based machine, such as pulling a handle or pushing a button. Online everything is accomplished by clicking your mouse button.
There is one other area - which will be of great interest to you - where there is a subtle but important difference between online slot machines and ones in land-based casinos. This is that the payout percentage at online casinos is often higher than at real-world ones. This means that the casino's "hold" or it's advantage over you is slightly less, making your time spent online more profitable over time.
The difference is small, often not more than one percentage point, but it all adds up in the end, and can be the difference between ending up slightly ahead or slightly down.